產(chǎn)品名稱 TBOA ammonia salt, L- - TBOA | (3S)-3-(Phenylmethoxy)-L-aspartic acid ammonia salt
產(chǎn)品貨號(hào) Axon 2427 CAS [N.A.] MF C11H13NO5.NH3MW 256.26 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Very potent blocker for the human excitatory amino acid transporters (EAAT1–3; IC50 values 23 μM, 3.8 μM, 7.0 μM for EAAT1, EAAT2, and EAAT3, respectively). L-TBOA is the most active isomer of DL-TBOA, as sold by competitors, and approximately twice as potent for inhibition of EAAT1 and EAAT2.
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TBOA ammonia salt, L- - TBOA | (3S)-3-(Phenylmethoxy)-L-aspartic acid ammonia salt

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2427

CAS [N.A.]

MF C11H13NO5.NH3
MW 256.26

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

TBOA ammonia salt, L-

Description

Very potent blocker for the human excitatory amino acid transporters (EAAT1–3; IC50 values 23 μM, 3.8 μM, 7.0 μM for EAAT1, EAAT2, and EAAT3, respectively). L-TBOA is the most active isomer of DL-TBOA, as sold by competitors, and approximately twice as potent for inhibition of EAAT1 and EAAT2.?

? ? EAAT1 EAAT2 EAAT3
? ? (IC50?μM) (IC50?μM) (IC50?μM)
? dl-TBOA 48 ± 4.1 7.0 ± 1.1 8.0 ± 1.9
? l-TBOA 23 ± 4.4 3.8 ± 1.0 7.0 ± 1.5
? d-TBOA 637 ± 175 64 ± 14 21 ± 2.3


IC50?values of THA derivatives for blocking [14C]glutamate uptake in COS-1 cells expressing EAAT1–3 (data taken from?Shimamoto et al.)
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