產(chǎn)品名稱 TFB-TBOA
產(chǎn)品貨號 Axon 2640 CAS [480439-73-4] MF C19H17F3N2O6MW 426.34 Purity: 100% Optical purity: >97% d.e. Soluble in 0.1N NaOH(aq) and DMSO Description Very potent blocker for the human excitatory amino acid transporters (IC50 values 22 nM, 17 nM, and 300 nM, for EAAT1, EAAT2, and EAAT3, respectively). TFB-BOA is more potent at inhibiting EAAT1 and EAAT2 compared with L-TBOA (Axon 2427), and induced spontaneous epileptiform discharges and convulsive behaviors in mice. An important tool for elucidation of the physiological roles of EAATs and their contribution to the etiology of neuronal disorders. KEYWORDS: TFB-TBOA | supplier | EAAT blocker | L-TFB-TBOA | CAS [480439-73-4] | Glutamate | EAAT1 | EAAT2 | Blocker | excitatory amino acid transporter | convulsion | neuronal | CNS
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產(chǎn)品品牌 axonmedchem
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TFB-TBOA

Based on 56 publications in PubMed 9 10 56

Axon 2640

CAS [480439-73-4]

MF C19H17F3N2O6
MW 426.34

  • Purity: 100%
  • Optical purity: >97% d.e.
  • Soluble in 0.1N NaOH(aq) and DMSO

TFB-TBOA

Description

Very potent blocker for the human excitatory amino acid transporters (IC50 values 22 nM, 17 nM, and 300 nM, for EAAT1, EAAT2, and EAAT3, respectively). TFB-BOA is more potent at inhibiting EAAT1 and EAAT2 compared with L-TBOA (Axon 2427), and induced spontaneous epileptiform discharges and convulsive behaviors in mice. An important tool for elucidation of the physiological roles of EAATs and their contribution to the etiology of neuronal disorders.

KEYWORDS: TFB-TBOA | supplier | EAAT blocker | L-TFB-TBOA | CAS [480439-73-4] | Glutamate | EAAT1 | EAAT2 | Blocker | excitatory amino acid transporter | convulsion | neuronal | CNS
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