| 產(chǎn)品名稱(chēng) | WAY 262611 dihydrochloride |
| 產(chǎn)品貨號(hào) | Axon 2188 CAS [N.A.] MF C20H22N4.2HClMW 391.34 Purity: 99% Soluble in water and DMSO Description Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously. References Certificates Categories Extra info J.C. Pelletier et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J. Med. Chem. 2009, 52, 6962-6965.? ? J.J. Pinzone et al. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood 2009, 113, 517-525.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell Wnt-β-Catenin Wnt Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist Chemical name (1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine dihydrochloride Parent CAS No. [1123231-07-1] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢(xún)價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
WAY 262611 dihydrochlorideAxon 2188 CAS [N.A.] MF C20H22N4.2HCl
Description
Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously.
Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist
Chemical name(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine dihydrochloride Parent CAS No.[1123231-07-1] |
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