產(chǎn)品名稱(chēng) Bizine
產(chǎn)品貨號(hào) Axon 2306 CAS [N.A.] MF C18H23N3O.HClMW 333.86 Purity: 98% Soluble in water and DMSO Description Potent LSD1 inhibitor in vitro and selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2 with Ki(inact) values 0.059 μM, 2.6 μM, 6.5 μM, and ca 11 μM for LSD1, MAO-A, MAO-B, and LSD2 respectively. Bizine was found to be effective at modulating bulk histone methylation in cancer cells. Moreover, neurons exposed to oxidative stress were protected by the presence of bizine, suggesting potential applications in neurodegenerative disease. References Certificates Categories Extra info P. Prusevich et al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem. Biol. 2014, 9, 1284-1293. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Epigenetics Immunology EC 1.14.11 Histone demethylase Potent LSD1 inhibitor with selectivity over MAO-A/B, and LSD2 Chemical name N-(4-(2-hydrazinylethyl)phenyl)-4-phenylbutanamide hydrochloride Parent CAS No. [1591932-50-1] Order Size Unit Price Stock 10 mg €120.00 In Stock
產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
產(chǎn)品規(guī)格
產(chǎn)品品牌 axonmedchem
產(chǎn)品概述
產(chǎn)品詳情

Bizine

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2306

CAS [N.A.]

MF C18H23N3O.HCl
MW 333.86

  • Purity: 98%
  • Soluble in water and DMSO

Bizine

Description

Potent LSD1 inhibitor in vitro and selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2 with Ki(inact) values 0.059 μM, 2.6 μM, 6.5 μM, and ca 11 μM for LSD1, MAO-A, MAO-B, and LSD2 respectively. Bizine was found to be effective at modulating bulk histone methylation in cancer cells. Moreover, neurons exposed to oxidative stress were protected by the presence of bizine, suggesting potential applications in neurodegenerative disease.
產(chǎn)品資料