產(chǎn)品名稱

YUKA1

產(chǎn)品貨號

Axon 2674 CAS [708991-09-7] MF C13H16N4O2SMW 292.36 Purity: 99% Soluble in DMSO Description YUKA1 is a cell-permeable selective inhibitor of lysine demethylase 5A (KDM5A/RBP2/JARID1A) (IC50 value 2.66 μM). YUKA1 blocks drug resistance and cancer cell growth in HeLa cervical cancer cells and ZR-75-1 breast cancer cells. YUKA1 was able to increase H3K4me3 levels in human cells and selectively inhibited the proliferation of cancer cells whose growth depends on KDM5A. KEYWORDS: YUKA1 | supplier | KDM5A inhibitor | YUKA-1 | YUKA 1 | CAS [708991-09-7] | Histone | Histone demethylase | Inhibitor | Enzymes | KDM5A | RBP2 | JARID1A

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

YUKA1

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2674

CAS [708991-09-7]

MF C13H16N4O2S
MW 292.36

Purity: 99%
Soluble in DMSO

YUKA1

Description

YUKA1 is a cell-permeable selective inhibitor of lysine demethylase 5A (KDM5A/RBP2/JARID1A) (IC50 value 2.66 μM). YUKA1 blocks drug resistance and cancer cell growth in HeLa cervical cancer cells and ZR-75-1 breast cancer cells. YUKA1 was able to increase H3K4me3 levels in human cells and selectively inhibited the proliferation of cancer cells whose growth depends on KDM5A.

M Gale et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Epigenetics EC 1.14.11 Histone demethylase

Selective inhibitor of KDM5A demethylase

Chemical name

4-(2-(Allyloxy)-3-methoxybenzylamino)-4H-1,2,4-triazole-3-thiol

Parent CAS No.

[708991-09-7]

產(chǎn)品資料