產(chǎn)品名稱(chēng)

PHA-767491

產(chǎn)品貨號(hào)

Axon 2690 CAS [845714-00-3] MF C12H11N3OMW 213.24 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description PHA-767491 is an ATP mimetic dual CDC7/CDK9 kinase inhibitor (IC50 values of 10 nM and 34 nM for CDC7 and CDK9, respectively). Treatment with PHA-767491 results in apoptotic cell death in multiple cancer cell types and tumor growth inhibition in preclinical cancer models. PHA-767491 is also a potent kinase inhibitor of MAPKAP-K2 (or MK-2) (IC50 value of 171 nM). KEYWORDS: PHA-767491 | supplier | CDC7/CDK9 inhibitor | PHA767491 | PHA 767491 | CAS [845714-00-3] | DNA-RNA | CDC7 | CDK9 | Inhibitor | Enzymes | [942425-68-5] | MK-2 | MAPKAPK2

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PHA-767491

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 2690

CAS [845714-00-3]

MF C12H11N3O
MW 213.24

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

PHA-767491

Description

PHA-767491 is an ATP mimetic dual CDC7/CDK9 kinase inhibitor (IC50 values of 10 nM and 34 nM for CDC7 and CDK9, respectively). Treatment with PHA-767491 results in apoptotic cell death in multiple cancer cell types and tumor growth inhibition in preclinical cancer models. PHA-767491 is also a potent kinase inhibitor of MAPKAP-K2 (or MK-2) (IC50 value of 171 nM).

KEYWORDS: PHA-767491 | supplier | CDC7/CDK9 inhibitor | PHA767491 | PHA 767491 | CAS [845714-00-3] | DNA-RNA | CDC7 | CDK9 | Inhibitor | Enzymes | [942425-68-5] | MK-2 | MAPKAPK2

DR Anderson et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.

E Vanotti et al. Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem. 2008 Feb 14;51(3):487-501.

A Montagnoli et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology MAPK DNA-damage Response EC 2.7.11.1 CDC7 CDK CDK9

Dual CDC7/CDK9 kinase inhibitor

Chemical name

2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one

Parent CAS No.

[845714-00-3]

產(chǎn)品資料