| 產(chǎn)品名稱 | VX 680 - MK 0457 | Tozasertib |
| 產(chǎn)品貨號(hào) | Axon 1540 CAS [639089-54-6] MF C23H28N8OSMW 464.59 Purity: 98% Soluble in DMSO Description Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases References Certificates Categories Extra info EA Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine? 10, 262 - 267 (2004)? ? GM Cheetham et al.?Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.? Cancer Lett. 2007, 251,? 323-329. ? FJ Giles et al.?MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.?Blood 2007, 109,? 500-502. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora Aurora inhibitor (non-specific) Chemical name Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide Parent CAS No. [639089-54-6] Order Size Unit Price Stock 10 mg €60.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
VX 680 - MK 0457 | TozasertibAxon 1540 CAS [639089-54-6] MF C23H28N8OS
Description
Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases
Aurora inhibitor (non-specific)
Chemical nameCyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide Parent CAS No.[639089-54-6] |
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