產(chǎn)品名稱

HIF-2a Translation Inhibitor 76

產(chǎn)品貨號(hào)

Axon 2614 CAS [882268-69-1] MF C9H9N3O4S2MW 287.32 Purity: 99% Soluble in DMSO Description HIF-2a translation inhibitor (IC50 value 5 μM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element). KEYWORDS:?HIF-2a Translation Inhibitor 76 | supplier | HIF2a translation inhibitor | CAS [882268-69-1] | DNA-RNA | HIF-2α | Transcription Factor | Iron-Responsive Element | IRE | mTOR | hypoxia | IRP1

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現(xiàn)貨詢價(jià)，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

HIF-2a Translation Inhibitor 76

Based on 2 reference(s) in Google Scholar 9 10 2

Axon 2614

CAS [882268-69-1]

MF C9H9N3O4S2
MW 287.32

Purity: 99%
Soluble in DMSO

HIF-2a Translation Inhibitor 76

Description

HIF-2a translation inhibitor (IC50 value 5 μM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).

M Zimmer et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008 Dec 26;32(6):838-48.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Cell Signaling & Oncology Epigenetics Transcription Factors TF class 1.2.5 HIF

HIF-2a translation inhibitor that works independent of mTOR

Chemical name

Methyl 3-(2-(cyano(methylsulfonyl)methylene)hydrazinyl)thiophene-2-carboxylate

Parent CAS No.

[882268-69-1]

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