產(chǎn)品名稱(chēng)

AZ 23

產(chǎn)品貨號(hào)

Axon 1610 CAS [915720-21-7] MF C17H19ClFN7OMW 391.83 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and selective tyrosine kinase (Trk) inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively; AZ-23 showed in vivo TrkA kinase inhibition and efficacy in mice following oral administration; having potential for therapeutic utility in neuroblastoma and multiple other cancer indications. KEYWORDS: AZ 23 | supplier | TrkA inhibitor | AZ23 |CAS[915720-21-7] | Neurotrophin | Trk | Inhibitor | tyrosine kinase | TrkA | TrkB | neuroblastoma | cancer

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AZ 23

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1610

CAS [915720-21-7]

MF C17H19ClFN7O
MW 391.83

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

AZ 23

Description

Potent and selective tyrosine kinase (Trk) inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively; AZ-23 showed in vivo TrkA kinase inhibition and efficacy in mice following oral administration; having potential for therapeutic utility in neuroblastoma and multiple other cancer indications.

K Thress et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol. Cancer Ther. 2009, 8(7), 1818-1827.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology RTK class VII; EC 2.7.10.1 Trk

TrkA and TrkB inhibitor

Chemical name

(S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Parent CAS No.

[915720-21-7]

產(chǎn)品資料