產(chǎn)品名稱

Reversine

產(chǎn)品貨號

Axon 1629 CAS [656820-32-5] MF C21H27N7OMW 393.49 Purity: 99% Soluble in DMSO Description Reversine induces differentiated myogenic-lineage committed cells to become multipotent mesenchymal progenitor cells; it is a potent mitotic inhibitor of MPS1 kinase, which inhibits the spindle assembly checkpoint in a dose-dependent manner; also acts as A3 adenosine receptor antagonist (Ki: 660 nM) or aurora kinases inhibitor (IC50: 400-500 nM for Aurora A/B/C respectively). KEYWORDS: Reversine | supplier | MPS1 inhibitor | CAS [656820-32-5] | Non Selective (Mitotic Spindle Checkpoint) | MPS1 Kinase | Inhibitor | Enzymes

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產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Reversine

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1629

CAS [656820-32-5]

MF C21H27N7O
MW 393.49

Purity: 99%
Soluble in DMSO

Reversine

Description

Reversine induces differentiated myogenic-lineage committed cells to become multipotent mesenchymal progenitor cells; it is a potent mitotic inhibitor of MPS1 kinase, which inhibits the spindle assembly checkpoint in a dose-dependent manner; also acts as A3 adenosine receptor antagonist (Ki: 660 nM) or aurora kinases inhibitor (IC50: 400-500 nM for Aurora A/B/C respectively).

M Saraiya et al. Reversine Enhances Generation of Progenitor-like Cells by Dedifferentiation of Annulus Fibrosus Cells. Tissue Eng. Part A. 2010, 16(4), 1443–1455.

S Santaguida etal. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J. Cell Biol. 2010, 190(1), 73-87.

AM D'Alise et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol. Cancer Ther. 2008, 7(5), 1140-1149.

L Anastasia et al. Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death and Differentiation 2006, 13, 2042–2051.

S Chen et al. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 2004, 126, 410-411.

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell MPS1 Kinase EC 2.7.12.1 Stem Cell Differentiator

MPS1 kinase inhibitor

Chemical name

N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine

Parent CAS No.

[656820-32-5]

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