產品名稱

TC Mps1 12

產品貨號

Axon 2755 CAS [1206170-62-8] MF C17H20N6OMW 324.38 Purity: 99% Soluble in DMSO Description Potent and selective Mps1 (TTK) kinase inhibitor (IC50 value of 6.4 nM) with good cellular activity, pharmacokinetic properties and efficacy in the A549 lung cancer xenograft model. Additionally, TC Mps1 12 suppressed the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. KEYWORDS: TC Mps1 12 | supplier | Mps1 inhibitor | CAS [1206170-62-8] | Non Selective (Mitotic Spindle Checkpoint) | MPS1 Kinase | Inhibitor | Enzymes | TTK

產品價格

現貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

TC Mps1 12

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2755

CAS [1206170-62-8]

MF C17H20N6O
MW 324.38

Purity: 99%
Soluble in DMSO

TC Mps1 12

Description

Potent and selective Mps1 (TTK) kinase inhibitor (IC50 value of 6.4 nM) with good cellular activity, pharmacokinetic properties and efficacy in the A549 lung cancer xenograft model. Additionally, TC Mps1 12 suppressed the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.

K Ken-ichi et al. Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation. ACS Med Chem Lett. 2012 Jul 12; 3(7): 560–564.

M Choi et al. TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br J Pharmacol. 2017 Jun;174(12):1810-1825.

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell MPS1 Kinase EC 2.7.12.1

Potent and selective inhibitor of MPS1 kinase

Chemical name

4-(4-Amino-6-(tert-butylamino)-5-cyanopyridin-2-ylamino)benzamide

Parent CAS No.

[1206170-62-8]

產品資料