產(chǎn)品名稱(chēng) S3I 201 - NSC 74859
產(chǎn)品貨號(hào) Axon 2313 CAS [501919-59-1] MF C16H15NO7SMW 365.36 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent, cellular STAT3 inhibitor that inhibits Stat3·Stat3 complex formation and Stat3 DNA-binding and transcriptional activities (IC50 value 86 μm for in vitro Stat3–Stat3:DNA disruption). S3I 201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. Additionally, S3I 201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo. S3I 201 showed cytotoxic activity against a wide variety of cancer cell lines (IC50 values ranging from 37.9 to 82.6 μm) through inhibition of the reductases P5, protein disulfide isomerase (PDI), thiol-disulfide oxidoreductase ERp57, and/or Trx. References Certificates Categories Extra info K. Siddiquee et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl. Acad. Sci. USA. 2007, 104, 7391-7396. ? S. Fletcher et al. Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities. Chembiochem. 2009, 10, 1959-1964. ? T. Horibe et al. Discovery of protein disulfide isomerase P5 inhibitors that reduce the secretion of MICA from cancer cells. Chembiochem. 2014, 15, 1599-1606. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Immunology Stem Cell Transcription Factors JAK-STAT TF class 4.2.1 STAT3 Potent, cellular STAT3 inhibitor Chemical name 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid Parent CAS No. [501919-59-1] Order Size Unit Price Stock 10 mg €95.00 In Stock
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S3I 201 - NSC 74859

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2313

CAS [501919-59-1]

MF C16H15NO7S
MW 365.36

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

S3I 201

Description

Potent, cellular STAT3 inhibitor that inhibits Stat3·Stat3 complex formation and Stat3 DNA-binding and transcriptional activities (IC50 value 86 μm for in vitro Stat3–Stat3:DNA disruption). S3I 201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. Additionally, S3I 201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo. S3I 201 showed cytotoxic activity against a wide variety of cancer cell lines (IC50 values ranging from 37.9 to 82.6 μm) through inhibition of the reductases P5, protein disulfide isomerase (PDI), thiol-disulfide oxidoreductase ERp57, and/or Trx.
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