產品名稱 Ruxolitinib - INCB 018424 phosphate
產品貨號 Axon 1598 CAS [1092939-17-7] MF C17H18N6.H3O4PMW 404.36 Purity: 99% Optical purity: 98% ee Soluble in water and DMSO Description An orally bioavailable, potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; selectivity >100 fold for a wide range of other kinases. It acts by blocking the JAK/STAT pathway References Certificates Categories Extra info RA?Mesa. Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. IDrugs. 2010, 13(6), 394-403. ? C Campas-Moya. Ruxolitinib. Drugs Fut. 2010, 35(6), 457.? ? S Verstovsek et al.?Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis.?N. Engl. J. Med.?2010, 363(12),?1117-1127. ? A Quintas-Cardama et al.?Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.?Blood?2010, 115(15),?3109-3117. ? E Apostolidou et al.?JAK2 inhibitors: a reality? a hope??Clin. Lymp Myel.?2009,?9(Suppl. 3),?S340-S345. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics JAK-STAT EC 2.7.10.2 JAK JAK1 and JAK2 inhibitor Chemical name (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate Parent CAS No. [941678-49-5] Order Size Unit Price Stock 2 mg €70.00 In Stock
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Ruxolitinib - INCB 018424 phosphate

Based on 620 publications in PubMed 10 10 620

Axon 1598

CAS [1092939-17-7]

MF C17H18N6.H3O4P
MW 404.36

  • Purity: 99%
  • Optical purity: 98% ee
  • Soluble in water and DMSO

Ruxolitinib

Description

An orally bioavailable, potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; selectivity >100 fold for a wide range of other kinases. It acts by blocking the JAK/STAT pathway
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