產(chǎn)品名稱

G? 6983 - GO 6983 | Goe 6983

產(chǎn)品貨號

Axon 2466 CAS [133053-19-7] MF C26H26N4O3MW 442.51 Purity: 99% Soluble in DMSO Description Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). G?6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science. *Promotion

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現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

G? 6983 - GO 6983 | Goe 6983

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2466

CAS [133053-19-7]

MF C26H26N4O3
MW 442.51

Purity: 99%
Soluble in DMSO

G? 6983

Description

Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). G?6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.

*Promotion: G? 6983 is also part of Inhibitor Set(s):

Axon 5010

M. Gschwendt et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.

I. Iankov et al. The effect of chemical blockade of PKC with G?6976 and G?6983 on proliferation and MAPK activity in IL-6-dependent plasmacytoma cells. Leuk Res. 2002 Apr;26(4):363-8.

K.C. Hwang et al. Chemicals that modulate stem cell differentiation. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7467-71.

O. Gafni et al. Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6.

L.H. Young et al. G? 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev. 2005 Fall;23(3):255-72.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology Pain & Inflammation Stem Cell NF-κB MAPK PI3K-Akt-mTOR EC 2.7.11.13 Stem Cell Differentiator PKC

Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ

Chemical name

3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Parent CAS No.

[133053-19-7]

產(chǎn)品資料