產(chǎn)品名稱

NG 25 trihydrochloride

產(chǎn)品貨號

Axon 2366 CAS [2108554-00-1] MF C29H30F3N5O2.3HClMW 646.96 Purity: 98% Soluble in water and DMSO Description Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 μM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells. KEYWORDS: NG 25 trihydrochloride | supplier | TAK1 (MAP3K7) and MAP4K2 inhibitor | NG25 | CAS [2108554-00-1] | [1315355-93-1] | MAPK | MAP3K | MAP4K | Lck | RAF | ERK | IKKβ | LYN | CSK | Abl | FER | p38α | SRC | NF-kappaB | TNF | Interferon | Immunology | PDC | Toll like | TLR | Inhibitor | Enzymes

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

NG 25 trihydrochloride

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2366

CAS [2108554-00-1]

MF C29H30F3N5O2.3HCl
MW 646.96

Purity: 98%
Soluble in water and DMSO

NG 25 trihydrochloride

Description

Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 μM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.

KEYWORDS: NG 25 trihydrochloride | supplier | TAK1 (MAP3K7) and MAP4K2 inhibitor | NG25 | CAS [2108554-00-1] | [1315355-93-1] | MAPK | MAP3K | MAP4K | Lck | RAF | ERK | IKKβ | LYN | CSK | Abl | FER | p38α | SRC | NF-kappaB | TNF | Interferon | Immunology | PDC | Toll like | TLR | Inhibitor | Enzymes

L. Tan et al. Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). J. Med. Chem. 2014 Jul 30. [Epub ahead of print]

E. Pauls et al. Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J. Biol. Chem. 2012, 287, 19216-19228.

N. Dzamko et al. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS One. 2012, 7, e39132.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Immunology Pain & Inflammation Lck Lyn NF-κB TGF-β EC 2.7.11.25 MAP3K MAP4K

Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK)

Chemical name

3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide trihydrochloride

Parent CAS No.

[1315355-93-1]

產(chǎn)品資料