| 產(chǎn)品名稱 | PF 06260933 dihydrochloride |
| 產(chǎn)品貨號 | Axon 2545 CAS [N.A.] MF C16H13ClN4.2HClMW 369.68 Purity: 99% Soluble in water and DMSO Description Potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content. KEYWORDS: PF 06260933 dihydrochloride | supplier | MAP4K4 inhibitor | PF06260933 | CAS [1811510-56-1] | MAPK | MAP4K | Inhibitor | HGK | ZC1 | mitogen activated | endothelial | diabetes | vascular inflammation | atherosclerosis | TNF | NF-κB |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
PF 06260933 dihydrochlorideAxon 2545 CAS [N.A.] MF C16H13ClN4.2HCl
DescriptionPotent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content. KEYWORDS: PF 06260933 dihydrochloride | supplier | MAP4K4 inhibitor | PF06260933 | CAS [1811510-56-1] | MAPK | MAP4K | Inhibitor | HGK | ZC1 | mitogen activated | endothelial | diabetes | vascular inflammation | atherosclerosis | TNF | NF-κB
Potent and selective MAP4K4 inhibitor
Chemical name5-(4-chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride Source informationPfizer compound; Sold for research purposes under agreement from Pfizer Inc.Parent CAS No.[1811510-56-1] |
| 產(chǎn)品資料 |
