產(chǎn)品名稱 Selexipag - NS 304 | ACT 293987 | Uptravi
產(chǎn)品貨號 Axon 2605 CAS [475086-01-2] MF C26H32N4O4SMW 496.62 Purity: 100% Soluble in DMSO Description Orally available and long-acting prodrug of MRE 269, a potent and highly selective IP receptor agonist (Ki values 20 nM and 260 nM for inhibition of [3H]iloprost binding to human IP receptor by MRE 269 and Selexipag, respectively). Capable of ameliorating vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy. Furthermore, Selexipag (NS 304) elevated right ventricular systolic pressure and improved survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT). KEYWORDS:?Selexipag | supplier | IP agonist prodrug | NS 304 | ACT 293987 | NS304 | ACT293987 | CAS [475086-01-2] - [1267423-51-7] | Prostaglandins | PGI2 (IP) | Agonist | MRE269 | prodrug | prostacyclin | PGI2 | pulmonary | hypertension | vascular | endothelial | dysfunction | hypertrophy
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產(chǎn)品品牌 axonmedchem
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Selexipag - NS 304 | ACT 293987 | Uptravi

Based on 38 publications in PubMed 9 10 38

Axon 2605

CAS [475086-01-2]

MF C26H32N4O4S
MW 496.62

  • Purity: 100%
  • Soluble in DMSO

Selexipag

Description

Orally available and long-acting prodrug of MRE 269, a potent and highly selective IP receptor agonist (Ki values 20 nM and 260 nM for inhibition of [3H]iloprost binding to human IP receptor by MRE 269 and Selexipag, respectively). Capable of ameliorating vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy. Furthermore, Selexipag (NS 304) elevated right ventricular systolic pressure and improved survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT).

KEYWORDS:?Selexipag | supplier | IP agonist prodrug | NS 304 | ACT 293987 | NS304 | ACT293987 | CAS [475086-01-2] - [1267423-51-7] | Prostaglandins | PGI2 (IP) | Agonist | MRE269 | prodrug | prostacyclin | PGI2 | pulmonary | hypertension | vascular | endothelial | dysfunction | hypertrophy
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