產品名稱 ASK1 Inhibitor 10
產品貨號 Axon 2179 CAS [1005775-56-3] MF C21H21N5O.2HClMW 432.35 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, selective, and orally bioavailable ASK1 inhibitor (IC50: 14 nM) with no affinity for a representative panel of kinases (IC50: >10 μM), except for ASK2 (IC50: 0.51 μM). Compound 10 shows a high ligand-lipophilicity efficiency (LLE, pIC50–logD = 4.69) value, which avoids issues of undesirable physical properties and ADME (absorption, distribution, metabolism, and elimination) profiles and interactions with other protein kinases and adverse biological activities. References Certificates Categories Extra info Y. Terao et al. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 7326-7329.? Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology MAPK EC 2.7.11.35 MAP3K Potent, selective, and orally bioavailable ASK1 inhibitor Chemical name N-(6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide dihydrochloride Parent CAS No. [1005775-55-2] Order Size Unit Price Stock 10 mg €125.00 In Stock
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ASK1 Inhibitor 10

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2179

CAS [1005775-56-3]

MF C21H21N5O.2HCl
MW 432.35

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

ASK1 Inhibitor 10

Description

Potent, selective, and orally bioavailable ASK1 inhibitor (IC50: 14 nM) with no affinity for a representative panel of kinases (IC50: >10 μM), except for ASK2 (IC50: 0.51 μM). Compound 10 shows a high ligand-lipophilicity efficiency (LLE, pIC50–logD = 4.69) value, which avoids issues of undesirable physical properties and ADME (absorption, distribution, metabolism, and elimination) profiles and interactions with other protein kinases and adverse biological activities.
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