產品名稱

CD161

產品貨號

Axon 2776 CAS [1627716-22-6] MF C26H21N5O2MW 435.48 Purity: 98% Soluble in DMSO Description CD161 is a potent, orally active and selective BET bromodomain inhibitor (Ki values of 8.2 nM and 1.4 nM for BRD4 BD1 and BD2, respectively). CD161 inhibits cell growth in acute leukemia cell lines and breast cancer cell lines. Moreover, CD161 has an excellent oral pharmacokinetic profile and, orally administered, effectively inhibits tumor growth in mice. KEYWORDS: CD161 | supplier | BET inhibitor | CD-161 | CD 161 | CAS [1627716-22-6] | Histone | BET (BRD) | Inhibitor | Proteins | BRD4 | Leukemia | Breast Cancer | Bioavailable

產品價格

現貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

CD161

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2776

CAS [1627716-22-6]

MF C26H21N5O2
MW 435.48

Purity: 98%
Soluble in DMSO

CD161

Description

CD161 is a potent, orally active and selective BET bromodomain inhibitor (Ki values of 8.2 nM and 1.4 nM for BRD4 BD1 and BD2, respectively). CD161 inhibits cell growth in acute leukemia cell lines and breast cancer cell lines. Moreover, CD161 has an excellent oral pharmacokinetic profile and, orally administered, effectively inhibits tumor growth in mice.

Y Zhao et al. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J Med Chem. 2017 May 11;60(9):3887-3901.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Epigenetics BET (BRD)

Potent, selective, and orally active BET bromodomain inhibitor

Chemical name

4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole

Parent CAS No.

[1627716-22-6]

產品資料