產(chǎn)品名稱 OF-1
產(chǎn)品貨號 Axon 2442 CAS [919973-83-4] MF C17H18BrN3O4SMW 440.31 Purity: 99% Soluble in DMSO Description Potent Bromodomain inhibitor with selectivity for BRPF1 and BRPF2 (Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 μM. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. KEYWORDS: OF1 | supplier | BRPF inhibitor | OF-1 supplier | CAS [919973-83-4] | Histone | BRPF (BRD) | Inhibitor | SGC | Bromodomain | Chromatin | BRPF1 | BRPF1B | BRPF2 | BRD4 | TIF1a | FRAP | epigenetic | DNA
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OF-1

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2442

CAS [919973-83-4]

MF C17H18BrN3O4S
MW 440.31

  • Purity: 99%
  • Soluble in DMSO

OF-1

Description

Potent Bromodomain inhibitor with selectivity for BRPF1 and BRPF2 (Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 μM. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay.

KEYWORDS: OF1 | supplier | BRPF inhibitor | OF-1 supplier | CAS [919973-83-4] | Histone | BRPF (BRD) | Inhibitor | SGC | Bromodomain | Chromatin | BRPF1 | BRPF1B | BRPF2 | BRD4 | TIF1a | FRAP | epigenetic | DNA
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