| 產(chǎn)品名稱 | CP 100356 hydrochloride |
| 產(chǎn)品貨號(hào) | Axon 1654 CAS [142715-48-8 ] MF C31H36N4O6.HClMW 597.10 Purity: 98% Soluble in DMSO Description Potent inhibitor of P-glycoprotein (P-gp), with Ki to be 58 and 94 nM for 1a and 1b isomers of P-gp; an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux References Certificates Categories Extra info C Wandel et al. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999, 59, 3944. ? JC Taylor et al. The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Br. J. Cancer 1999, 81(5), 783-789. ? AS Kalgutkar et al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" (...). J. Pharm. Sci. 2009, 98, 4914. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS P-glycoprotein Unclassified P-gp inhibitor Chemical name 4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine Parent CAS No. [142716-85-6] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
CP 100356 hydrochlorideAxon 1654 CAS [142715-48-8 ] MF C31H36N4O6.HCl
Description
Potent inhibitor of P-glycoprotein (P-gp), with Ki to be 58 and 94 nM for 1a and 1b isomers of P-gp; an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux
P-gp inhibitor
Chemical name4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine Parent CAS No.[142716-85-6] |
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