| 產(chǎn)品名稱 | LCS-1 |
| 產(chǎn)品貨號 | Axon 2176 CAS [41931-13-9] MF C11H8Cl2N2OMW 255.10 Purity: 99% Soluble in DMSO Description Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways. KEYWORDS:?LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
LCS-1Axon 2176 CAS [41931-13-9] MF C11H8Cl2N2O
DescriptionInhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways. KEYWORDS:?LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer
Inhibits SOD1 enzymatic activity. Lead compound for lung cancer therapeutics
Chemical name4,5-dichloro-2-m-tolylpyridazin-3(2H)-one Parent CAS No.[41931-13-9] |
| 產(chǎn)品資料 |
