產(chǎn)品名稱(chēng) APS-2-79
產(chǎn)品貨號(hào) Axon 2611 CAS [2002381-31-7] MF C23H21N3O3.HClMW 423.89 Purity: 98% Soluble in DMSO Description Small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling. KEYWORDS:?APS-2-79 | supplier | KSR/Raf inhibitor | APS2-79 | CAS [2002381-31-7] | [ 2002381-25-9] | MEK | KSR2 | Kinase suppressor of Ras | Raf | MAPK | K-Ras | mitogen activated | oncogenic
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APS-2-79

Based on 4 reference(s) in Google Scholar 9 10 4

Axon 2611

CAS [2002381-31-7]

MF C23H21N3O3.HCl
MW 423.89

  • Purity: 98%
  • Soluble in DMSO

APS-2-79

Description

Small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Furthermore, APS-2-79 modulates KSR-dependent MAPK signaling, and increases the potency of several MEK inhibitors, specifically within Ras-mutant cell lines by antagonizing release of negative feedback signaling.

KEYWORDS:?APS-2-79 | supplier | KSR/Raf inhibitor | APS2-79 | CAS [2002381-31-7] | [ 2002381-25-9] | MEK | KSR2 | Kinase suppressor of Ras | Raf | MAPK | K-Ras | mitogen activated | oncogenic
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