NSC 23766

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1578

CAS [1177865-17-6]

MF C24H35N7.3HCl
MW 530.96

Purity: 99%
Soluble in water and DMSO

NSC 23766

Description

A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM) without affecting the closely related GTPases, Cdc42, and RhoA activation.
A useful tool for studying the Rac-mediated cellular functions and for modulating pathological conditions in which Rac-deregulation may play a role.

M Vallon et al. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Exp. Cell Res. 2010, 316 412-421.?

EE Bosco et al. Rac1 GTPase: A “Rac” of all trades. Cell Mol. Life Sci. 2009,?66 370-374.?

J Wang et al. Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth. Biochem Biophys Res Commun 2009, 386 769-774.?

Hable W.E. Et al. The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. PLANTA 2008, 227(5), 991-1000.

JA Cancelas et al. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat. Med 2005, 11(8), 886-891.?

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology Stem Cell EC 3.6.5.2 Rac

Rac1 inhibitor

Chemical name

N*6*-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride

Parent CAS No.

[733767-34-5]

產(chǎn)品資料