產(chǎn)品名稱 HLCL65 hydrochloride
產(chǎn)品貨號(hào) Axon 2710 CAS [N.A.] MF C23H23BrN2O.HClMW 459.81 Purity: 99% Soluble in DMSO Description HLCL65 is a highly selective small molecule PRMT5 inhibitor. HLCL65 inhibited Th1 cell proliferation (IC50 value 1.1 μM) more potently than Th2 cell proliferation (IC50 value 4 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models. HLCL65 is a more potent and bioavailable derivative of CMP5 (Axon 2709). KEYWORDS: HLCL65 hydrochloride | supplier | PRMT5 inhibitor | HLCL-65 | HLCL 65 | CAS [1627865-11-5] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes
產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
產(chǎn)品規(guī)格
產(chǎn)品品牌 axonmedchem
產(chǎn)品概述
產(chǎn)品詳情

HLCL65 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2710

CAS [N.A.]

MF C23H23BrN2O.HCl
MW 459.81

  • Purity: 99%
  • Soluble in DMSO

HLCL65 hydrochloride

Description

HLCL65 is a highly selective small molecule PRMT5 inhibitor. HLCL65 inhibited Th1 cell proliferation (IC50 value 1.1 μM) more potently than Th2 cell proliferation (IC50 value 4 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.

HLCL65 is a more potent and bioavailable derivative of CMP5 (Axon 2709).

KEYWORDS: HLCL65 hydrochloride | supplier | PRMT5 inhibitor | HLCL-65 | HLCL 65 | CAS [1627865-11-5] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes
產(chǎn)品資料