| 產(chǎn)品名稱 | GW 311616A - GW 311616 hydrochloride |
| 產(chǎn)品貨號(hào) | Axon 2364 CAS [197890-44-1] MF C19H31N3O4S.HClMW 433.99 Purity: 99% Optical purity: >99% ee Soluble in water and DMSO Description Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. References Certificates Categories Extra info S.J. Macdonald et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. ? J.W. Cooke et al. A novel and selective approach to enantiomerically pure bicyclic-trans-lactams via a titanium enolate of a thiopyridyl ester. J Org Chem. 2001 Jan 12;66(1):334-6. ? S.J.F. Macdonald et al. A flexible, practical, and stereoselective synthesis of enantiomerically pure trans-5-oxohexahydropyrrolo[3,2-b]pyrroles (pyrrolidine-trans-lactams), a new class of serine protease....J.O.C. 1999? June 17, 64(14), 5166-5175. ? V. Papayannopoulos et al. Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy. PLoS One. 2011;6(12):e28526. Certificate of Analysis Material Safety Data Sheet Immunology Miscellaneous Pain & Inflammation EC 3.4.21.37 HNE Potent, selective and orally active human neutrophil elastase (HNE) inhibitor Chemical name (3S,3aS,6aR)-3-isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride Parent CAS No. [198062-54-3] Order Size Unit Price Stock 2 mg €135.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
GW 311616A - GW 311616 hydrochlorideAxon 2364 CAS [197890-44-1] MF C19H31N3O4S.HCl
Description
Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM.
Potent, selective and orally active human neutrophil elastase (HNE) inhibitor
Chemical name(3S,3aS,6aR)-3-isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride Parent CAS No.[198062-54-3] |
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