產(chǎn)品名稱

TY 52156

產(chǎn)品貨號

Axon 2404 CAS [934369-14-9] MF C18H19Cl2N3OMW 364.27 Purity: 99% Soluble in DMSO Description Selective, competitive, and orally active S1P3 antagonist that restores S1P reduced coronary blood flow, and inhibits Rho dependent activation and calcium signaling. TY52156 inhibited FTY720-induced S1P3 receptor-mediated bradycardia in vivo. References Certificates Categories Extra info A. Murakami et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010 Apr;77(4):704-13. ? N.J. Pyne et al. Selectivity and specificity of sphingosine 1-phosphate receptor ligands: "off-targets" or complex pharmacology? Front Pharmacol. 2011 May 31;2:26. ? K. Sobel et al. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem. 2013 May 24;288(21):14839-51. ? Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cardiovascular Immunology Miscellaneous A13 S1PR3 Selective, competitive, and orally active S1P3 antagonist Chemical name N,N'-bis(4-chlorophenyl)-3,3-dimethyl-2-oxobutanehydrazonamide Parent CAS No. [934369-14-9] Order Size Unit Price Stock 10 mg €125.00 In Stock

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現(xiàn)貨詢價，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TY 52156

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2404

CAS [934369-14-9]

MF C18H19Cl2N3O
MW 364.27

Purity: 99%
Soluble in DMSO

TY 52156

Description

Selective, competitive, and orally active S1P3 antagonist that restores S1P reduced coronary blood flow, and inhibits Rho dependent activation and calcium signaling. TY52156 inhibited FTY720-induced S1P3 receptor-mediated bradycardia in vivo.

A. Murakami et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010 Apr;77(4):704-13.

N.J. Pyne et al. Selectivity and specificity of sphingosine 1-phosphate receptor ligands: "off-targets" or complex pharmacology? Front Pharmacol. 2011 May 31;2:26.

K. Sobel et al. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem. 2013 May 24;288(21):14839-51.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Apoptosis Cardiovascular Immunology Miscellaneous A13 S1PR3

Selective, competitive, and orally active S1P3 antagonist

Chemical name

N,N'-bis(4-chlorophenyl)-3,3-dimethyl-2-oxobutanehydrazonamide

Parent CAS No.

[934369-14-9]

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