產(chǎn)品名稱 PF 543 citrate
產(chǎn)品貨號(hào) Axon 2350 CAS [1415562-83-2] MF C27H31NO4S.C6H8O7MW 657.73 Purity: 98% Optical purity: Optically pure Soluble in water and DMSO Description Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. References Certificates Categories Extra info D. Vogt et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg. Med. Chem. 2014, 22, 5354-5367. ? M.E. Schnute et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem. J. 2012, 444, 79-88. ? J. Wang et al. Crystal Structure of Sphingosine Kinase 1 with PF-543. ACS Med Chem Lett. 2014, 5, 1329-1333. Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Signaling & Oncology Immunology Miscellaneous Pain & Inflammation EC 2.7.1.91 SphK Pfizer Licensed Products Cell-permeant reversible inhibitor of SphK1 Chemical name (R)-(1-(4-((3-methyl-5-(phenylsulfonylmethyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 2-hydroxypropane-1,2,3-tricarboxylate Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [1415562-82-1] Order Size Unit Price Stock 5 mg €99.00 In Stock
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PF 543 citrate

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2350

CAS [1415562-83-2]

MF C27H31NO4S.C6H8O7
MW 657.73

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

PF 543 citrate

Description

Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
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