產(chǎn)品名稱 K 145 hydrochloride
產(chǎn)品貨號(hào) Axon 2235 CAS [1449240-68-9] MF C18H24N2O3S.HClMW 384.92 Purity: 99% Soluble in water and DMSO Description Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 μM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase. References Certificates Categories Extra info K. Liu et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013, 8, e56471.? Certificate of Analysis Material Safety Data Sheet Angiogenesis Apoptosis Cell Signaling & Oncology Immunology Miscellaneous EC 2.7.1.91 SphK Selective, substrate competitive SphK2 inhibitor Chemical name 3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride Parent CAS No. [1309444-75-4] Order Size Unit Price Stock 10 mg €105.00 In Stock
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K 145 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2235

CAS [1449240-68-9]

MF C18H24N2O3S.HCl
MW 384.92

  • Purity: 99%
  • Soluble in water and DMSO

K 145 hydrochloride

Description

Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 μM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase.
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