| 產(chǎn)品名稱 | NS 1619 |
| 產(chǎn)品貨號(hào) | Axon 2854 CAS [153587-01-0] MF C15H8F6N2O2MW 362.23 Purity: 98% Soluble in DMSO Description NS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax. KEYWORDS: NS 1619 | supplier | BK channel activator | NS1619 | NS-1619 | CAS [153587-01-0] | Potassium | KCa1.1 | Opener | Ion Channels | Apoptosis | Glioma | A2780 | p53 | p21 | Bax |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
NS 1619Axon 2854 CAS [153587-01-0] MF C15H8F6N2O2
DescriptionNS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax. KEYWORDS: NS 1619 | supplier | BK channel activator | NS1619 | NS-1619 | CAS [153587-01-0] | Potassium | KCa1.1 | Opener | Ion Channels | Apoptosis | Glioma | A2780 | p53 | p21 | Bax
Selective activator of large-conductance Ca2+-activated potassium (BK) channels
Chemical name1-(2-Hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one Parent CAS No.[153587-01-0] |
| 產(chǎn)品資料 |
