產(chǎn)品名稱 IBP, 4- - NSC 667672
產(chǎn)品貨號(hào) Axon 2919 CAS [155798-08-6] MF C19H21IN2OMW 420.29 Purity: 98% Soluble in DMSO Description 4-IBP is a selective sigma-1 (σ-1) agonist with Ki values of 1.70 nM and 25.2 nM for σ-1 and σ-2 receptor subtypes, respectively. Activating the σ-1 receptor with noncytotoxic doses of 4-IBP decreases the migration levels of various types of cancer cells, including C32 melanoma, U373-MG glioblastoma, A549 NSCLC, and PC3 prostate cancer cells. Moreover, 4-IBP sensitizes these cancer cells in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. KEYWORDS: 4-IBP | supplier | Sigma-1 agonist | NSC 667672 | 4IBP | 4 IBP | NSC667672 | NSC-667672 | CAS [155798-08-6] | Sigma Receptor Substrates | Sigma-1 | Antagonist | Receptors
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IBP, 4- - NSC 667672

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 2919

CAS [155798-08-6]

MF C19H21IN2O
MW 420.29

  • Purity: 98%
  • Soluble in DMSO

IBP, 4-

Description

4-IBP is a selective sigma-1 (σ-1) agonist with Ki values of 1.70 nM and 25.2 nM for σ-1 and σ-2 receptor subtypes, respectively. Activating the σ-1 receptor with noncytotoxic doses of 4-IBP decreases the migration levels of various types of cancer cells, including C32 melanoma, U373-MG glioblastoma, A549 NSCLC, and PC3 prostate cancer cells. Moreover, 4-IBP sensitizes these cancer cells in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs.

KEYWORDS: 4-IBP | supplier | Sigma-1 agonist | NSC 667672 | 4IBP | 4 IBP | NSC667672 | NSC-667672 | CAS [155798-08-6] | Sigma Receptor Substrates | Sigma-1 | Antagonist | Receptors

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