| 產(chǎn)品名稱(chēng) | PK-THPP |
| 產(chǎn)品貨號(hào) | Axon 2403 CAS [1332454-07-5] MF C29H32N4O2MW 468.59 Purity: 99% Soluble in DMSO Description Potent TASK-3 (KCNK9) antagonist (IC50 value 303 nM and 35nM for TASK-1 and TASK-3, respectively) with >140 fold selectivity over a wider range of potassium channels. PK-THPP produced a significant increase in active wake with a concurrent decrease in both REM and delta sleep immediately following administration to wild-type (WT) mice, and stimulated breathing by increasing tidal volume and breathing rate in isoflurane-anesthetized rats. PK-THPP induced a respiratory alkalosis and increased oxygenation. References Certificates Categories Extra info D.P. Flaherty et al. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3968-73. ? C.A. Coburn et al. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem. 2012 Jan 2;7(1):123-33. ? J.F. Cotten. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr;116(4):810-6. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Diabetes & Metabolism TASK-3 Potent TASK-3 antagonist with selectivity over a wide range of potassium channels Chemical name 1-(1-(6-(Biphenylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl)butan-1-one Parent CAS No. [1332454-07-5] Order Size Unit Price Stock 10 mg €145.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
PK-THPPAxon 2403 CAS [1332454-07-5] MF C29H32N4O2
Description
Potent TASK-3 (KCNK9) antagonist (IC50 value 303 nM and 35nM for TASK-1 and TASK-3, respectively) with >140 fold selectivity over a wider range of potassium channels. PK-THPP produced a significant increase in active wake with a concurrent decrease in both REM and delta sleep immediately following administration to wild-type (WT) mice, and stimulated breathing by increasing tidal volume and breathing rate in isoflurane-anesthetized rats. PK-THPP induced a respiratory alkalosis and increased oxygenation.
Potent TASK-3 antagonist with selectivity over a wide range of potassium channels
Chemical name1-(1-(6-(Biphenylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl)butan-1-one Parent CAS No.[1332454-07-5] |
| 產(chǎn)品資料 |
