| 產(chǎn)品名稱 | ML 297 - VU 0456810 |
| 產(chǎn)品貨號 | Axon 2436 CAS [1443246-62-5] MF C17H14F2N4OMW 328.32 Purity: 99% Soluble in DMSO Description First potent and selective activator of the GIRK potassium channel (EC50 value 0.16 μM for GIRK1/2 activation) with selectivity for GIRK1-containing GIRKs, exhibiting antiepileptic properties in vivo. ML297 showed equal or greater efficacy compared to a clinically active anti-seizure medication,sodium valproate, regardless of whether epilepsy was initiated chemically with PTZ or via electroshock. References Certificates Categories Extra info K. Kaufmann et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. Certificate of Analysis Material Safety Data Sheet CNS Pain & Inflammation GIRK KCNJ3 First potent and selective activator of the GIRK potassium channel Chemical name 1-(3,4-difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea Parent CAS No. [1443246-62-5] Order Size Unit Price Stock 10 mg €95.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
ML 297 - VU 0456810Axon 2436 CAS [1443246-62-5] MF C17H14F2N4O
Description
First potent and selective activator of the GIRK potassium channel (EC50 value 0.16 μM for GIRK1/2 activation) with selectivity for GIRK1-containing GIRKs, exhibiting antiepileptic properties in vivo. ML297 showed equal or greater efficacy compared to a clinically active anti-seizure medication,sodium valproate, regardless of whether epilepsy was initiated chemically with PTZ or via electroshock.
First potent and selective activator of the GIRK potassium channel
Chemical name1-(3,4-difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea Parent CAS No.[1443246-62-5] |
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