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產(chǎn)品名稱

SCH 79797 dihydrochloride

產(chǎn)品貨號

Axon 1275 CAS [1216720-69-2] MF C23H25N5.2HClMW 444.40 Purity: 99% Soluble in DMSO and Ethanol Description Potent and selective non-peptide PAR1 antagonist. KEYWORDS:?SCH 79797 dihydrochloride | supplier | PAR1 antagonist | SCH79797 HCl | CAS [1216720-69-2] | [245520-69-8] | Thrombin | PAR | myocardial | ischemia | reperfusion | GPCR | protease-activated receptor 1 | apoptosis | airway | inflammation | fibrosis

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SCH 79797 dihydrochloride

Based on 133 publications in PubMed 8 10 133

Axon 1275

CAS [1216720-69-2]

MF C23H25N5.2HCl
MW 444.40

Purity: 99%
Soluble in DMSO and Ethanol

SCH 79797 dihydrochloride

Description

Potent and selective non-peptide PAR1 antagonist.

KEYWORDS:?SCH 79797 dihydrochloride | supplier | PAR1 antagonist | SCH79797 HCl | CAS [1216720-69-2] | [245520-69-8] | Thrombin | PAR | myocardial | ischemia | reperfusion | GPCR | protease-activated receptor 1 | apoptosis | airway | inflammation | fibrosis

JI Strande et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Bas. Res. Cardiol. 2007, 102(4), 350.

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C di Serio et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism.?Bas. Clin. Pharmacol. Toxicol. 2007,?101(1),?63-69.

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E Sokolova and G Reiser. A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors. Pharmacol. Ther. 2007, 115(1), 70-83.

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P Zania et al.?Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis.?J. Pharm. Exp. Ther.?2006,?318(1),?246.

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HS Ahn et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem. Pharmacol. 2000, 60(10), 1425-1434.

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List of publications using SCH 79797 dihydrochloride (Axon 1275) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology A15 Thrombin (PAR)

PAR1 antagonist

Chemical name

N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

Parent CAS No.

[245520-69-8]

產(chǎn)品資料

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