產(chǎn)品名稱

AC 264613

產(chǎn)品貨號(hào)

Axon 2898 CAS [1051487-82-1] MF C19H18BrN3O2MW 400.27 Purity: 98% Soluble in DMSO Recently added

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AC 264613

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2898

CAS [1051487-82-1]

MF C19H18BrN3O2
MW 400.27

Purity: 98%
Soluble in DMSO

Recently added

AC 264613

Description

AC 264613 is a potent, selective, and metabolically stable protease activated receptor 2 (PAR2) agonist (pEC50 value of 6.7). The potency of AC 264613 in the cellular proliferation assay was approximately 50 nM, and was virtually the same at wild-type PAR2 receptors. Incubation of macrophages with AC 264613 caused a decrease of IRF5 expression and also significantly reduced p53 protein expression.

JG Seitzberg et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51(18):5490-3.

LR Gardell et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808.

R Yamaguchi et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40(6):629-41.

Certificate of Analysis
Material Safety Data Sheet

Diabetes & Metabolism Miscellaneous Pain & Inflammation A15 Thrombin (PAR)

Potent, selective, and metabolically stable PAR2 agonist

Chemical name

N'-(1-(3-Bromophenyl)ethylidene)-2-oxo-4-phenylpyrrolidine-3-carbohydrazide

Parent CAS No.

[1051487-82-1]

產(chǎn)品資料