產(chǎn)品名稱

Chloroquine diphosphate - NSC 14050

產(chǎn)品貨號

Axon 2431 CAS [50-63-5] MF C18H26ClN3.2H3PO4MW 515.86 Purity: 99% Optical purity: Racemate Soluble in water Description Classical antimalarial drug (CQ) with lysosomotropic effects causing necrosis and apoptosis. Inhibitor of hemozoin (β-?hematin) formation in malaria (Plasmodium strains) affected red blood cells. Nowadays, most of the Plasmodium falciparum strains are resistant to this drug. Chloroquine was found to inhibit the human thiamine transporter ThTr-2 (SLC19A3), and to inhibit cell growth and to induce cell death in A549 lung cancer cells. KEYWORDS: Chloroquine diphosphate | supplier | Antimalarial drug | NSC 14050 | NSC14050 | CQ | CAS [50-63-5] | [54-05-7] | beta-hematin | Plasmodium | hemoglobin | hemozoin | thiamine | transporter | ThTr-2 | SLC19A3 | apoptosis | necrosis

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axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Chloroquine diphosphate - NSC 14050

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2431

CAS [50-63-5]

MF C18H26ClN3.2H3PO4
MW 515.86

Purity: 99%
Optical purity: Racemate
Soluble in water

Chloroquine diphosphate

Description

Classical antimalarial drug (CQ) with lysosomotropic effects causing necrosis and apoptosis. Inhibitor of hemozoin (β-?hematin) formation in malaria (Plasmodium strains) affected red blood cells. Nowadays, most of the Plasmodium falciparum strains are resistant to this drug. Chloroquine was found to inhibit the human thiamine transporter ThTr-2 (SLC19A3), and to inhibit cell growth and to induce cell death in A549 lung cancer cells.

O. Dechy-Cabaret et al. Preparation and antimalarial activities of "trioxaquines", new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline. Chembiochem. 2000 Nov 17;1(4):281-3.

C. Fan et al. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells. Bioorg Med Chem. 2006 May 1;14(9):3218-22.

Z. Huang et al. Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. PLoS Genet. 2012;8(11):e1003083.

J. Gildenhuys et al. The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor. J Am Chem Soc. 2013 Jan 23;135(3):1037-47.

L. Tanenbaum et al. Antimalarial agents. Chloroquine, hydroxychloroquine, and quinacrine. Arch Dermatol. 1980 May;116(5):587-91.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Immunology Miscellaneous Pain & Inflammation Unclassified Antiprotozoal agents

Classical antimalarial drug causing necrosis and apoptosis

Chemical name

N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine bis(phosphate)

Parent CAS No.

[54-05-7]

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