產(chǎn)品名稱 Salermide
產(chǎn)品貨號(hào) Axon 2704 CAS [1105698-15-4] MF C26H22N2O2MW 394.47 Purity: 99% Soluble in DMSO Description Salermide is a reverse amide with a potent in vitro inhibitory effect on Sirt1 and Sirt2. Salermide was well tolerated by mice at concentrations up to 100 μM and prompted tumour-specific cell death in a wide range of human cancer cell lines. It induces massive apoptosis in cancer but not in non-transformed cultured cells. The apoptotic effect of Salermide is in part because of the reactivation of proapoptotic genes that are epigenetically repressed by Sirt1 exclusively in cancer cells. KEYWORDS: Salermide | supplier | SIRT inhibitor | CAS [1105698-15-4] | Histone | SIRT | Inhibitor | Enzymes
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Salermide

Based on 30 reference(s) in Google Scholar 9 10 30

Axon 2704

CAS [1105698-15-4]

MF C26H22N2O2
MW 394.47

  • Purity: 99%
  • Soluble in DMSO

Salermide

Description

Salermide is a reverse amide with a potent in vitro inhibitory effect on Sirt1 and Sirt2. Salermide was well tolerated by mice at concentrations up to 100 μM and prompted tumour-specific cell death in a wide range of human cancer cell lines. It induces massive apoptosis in cancer but not in non-transformed cultured cells. The apoptotic effect of Salermide is in part because of the reactivation of proapoptotic genes that are epigenetically repressed by Sirt1 exclusively in cancer cells.

KEYWORDS: Salermide | supplier | SIRT inhibitor | CAS [1105698-15-4] | Histone | SIRT | Inhibitor | Enzymes
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