產(chǎn)品名稱 BAY 58-2667 hydrochloride - Cinaciguat hydrochloride
產(chǎn)品貨號 Axon 2172 CAS [646995-35-9] MF C36H39NO5.HClMW 602.16 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator with haemodynamic effect similar to that of nitroglycerin (Ki value 6-8 nM in competition binding studies). Acts specifically on oxidized/haem-free sGC by binding to the enzyme's haem pocket and mimicking the nitric-oxide-bound haem group. BAY 58-2667 is in clinical development for the treatment of acute decompensated heart failure (ADHF). KEYWORDS:?BAY 58-2667 hydrochloride | supplier | sGC activator | Cinaciguat hydrochloride | BAY58-2667 | CAS [646995-35-9] | [329773-35-5] | GTP | sGC | soluble | guanylyl cyclase | NO | nitric oxide | heart failure | cardiac | ADHF
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BAY 58-2667 hydrochloride - Cinaciguat hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2172

CAS [646995-35-9]

MF C36H39NO5.HCl
MW 602.16

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

BAY 58-2667 hydrochloride

Description

Potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator with haemodynamic effect similar to that of nitroglycerin (Ki value 6-8 nM in competition binding studies). Acts specifically on oxidized/haem-free sGC by binding to the enzyme's haem pocket and mimicking the nitric-oxide-bound haem group. BAY 58-2667 is in clinical development for the treatment of acute decompensated heart failure (ADHF).

KEYWORDS:?BAY 58-2667 hydrochloride | supplier | sGC activator | Cinaciguat hydrochloride | BAY58-2667 | CAS [646995-35-9] | [329773-35-5] | GTP | sGC | soluble | guanylyl cyclase | NO | nitric oxide | heart failure | cardiac | ADHF
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