產(chǎn)品名稱 MYK-461 - Mavacamten | SAR439152
產(chǎn)品貨號 Axon 2683 CAS [1642288-47-8] MF C15H19N3O2MW 273.33 Purity: 100% Optical purity: Optically pure Soluble in 0.1 N NaOH(aq) and DMSO Description MYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM. KEYWORDS: MYK-461 | supplier | Myosin inhibitor | MYK461 | MYK 461 | CAS [1642288-47-8] | ATP | ATPase (cardiac specific myosin) | Inhibitor | Enzymes | Sarcomere | HCM | LVOT | Hypertrophic Cardiomyopathy | Left Ventricular Outflow Tract | Myosin
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MYK-461 - Mavacamten | SAR439152

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2683

CAS [1642288-47-8]

MF C15H19N3O2
MW 273.33

  • Purity: 100%
  • Optical purity: Optically pure
  • Soluble in 0.1 N NaOH(aq) and DMSO

MYK-461

Description

MYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM.

KEYWORDS: MYK-461 | supplier | Myosin inhibitor | MYK461 | MYK 461 | CAS [1642288-47-8] | ATP | ATPase (cardiac specific myosin) | Inhibitor | Enzymes | Sarcomere | HCM | LVOT | Hypertrophic Cardiomyopathy | Left Ventricular Outflow Tract | Myosin
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