產(chǎn)品名稱 MLN 4924 - Pevonedistat
產(chǎn)品貨號(hào) Axon 2038 CAS [905579-51-3] MF C21H25N5O4SMW 443.52 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description First-in-class inhibitor of NEDD8 Activating Enzyme (NAE) with potent antitumor activity in animal models; cell permeable; MLN4924 inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation References Certificates Categories Extra info TA Soucy et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009, 458, 732-736.?? ? TA Soucy et al. Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer. Clin. Cancer Res. 2009, 15, 3912.?? ? Y Zhao et al. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death and Disease 2012, 3, e386.? ? JL Toth et al. A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924. Cell Reports, 2012, 1(4), 309-316.? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology CNS Ubiquitin EC 6.2.1 Ubiquitin Ligase (E1) Inhibitor of NEDD8 Activating Enzyme (NAE) Chemical name ((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate Parent CAS No. [905579-51-3] Order Size Unit Price Stock 1 mg €75.00 In Stock
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MLN 4924 - Pevonedistat

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2038

CAS [905579-51-3]

MF C21H25N5O4S
MW 443.52

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

MLN 4924

Description

First-in-class inhibitor of NEDD8 Activating Enzyme (NAE) with potent antitumor activity in animal models; cell permeable; MLN4924 inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation
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