產(chǎn)品名稱 JTP 1048196
產(chǎn)品貨號 Axon 2947 CAS [55377-56-5] MF C17H14O4MW 282.29 Purity: 99% Soluble in DMSO Recently added
產(chǎn)品價格 現(xiàn)貨詢價，電話：010-67529703
產(chǎn)品規(guī)格
產(chǎn)品品牌 axonmedchem
產(chǎn)品概述
產(chǎn)品詳情

JTP 1048196

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2947

CAS [55377-56-5]

MF C17H14O4
MW 282.29

  • Purity: 99%
  • Soluble in DMSO
Recently added

JTP 1048196

Description

JTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16.1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex. The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 (Axon 2939) which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels.

KEYWORDS: JTP 1048196 | supplier | LUBAC inhibitor | JTP1048196 | JTP-1048196 | CAS [55377-56-5] | NF-κB Pathway | Ubiquitin Ligase (E3; LUBAC) | Inhibitor | Enzymes | HOIL-1L | HOIP | SHARPIN
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