產(chǎn)品名稱 AR7 - Atypical retinoid 7
產(chǎn)品貨號(hào) Axon 2679 CAS [80306-38-3] MF C15H12ClNOMW 257.71 Purity: 99,7% Soluble in DMSO Description Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells). KEYWORDS:?AR7 | ?supplier | RARα antagonist | Atypical retinoid 7 ?| AR-7 | AR 7 | CAS [80306-38-3] | Retinoic Acid | nuclear receptor | NR1B1 | chaperone-mediated | autophagy | CMA | hypoxia | cancer | neurodegenerative
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AR7 - Atypical retinoid 7

Based on 4 reference(s) in Google Scholar 9 10 4

Axon 2679

CAS [80306-38-3]

MF C15H12ClNO
MW 257.71

  • Purity: 99,7%
  • Soluble in DMSO

AR7

Description

Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells).

KEYWORDS:?AR7 | ?supplier | RARα antagonist | Atypical retinoid 7 ?| AR-7 | AR 7 | CAS [80306-38-3] | Retinoic Acid | nuclear receptor | NR1B1 | chaperone-mediated | autophagy | CMA | hypoxia | cancer | neurodegenerative
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