產(chǎn)品名稱 Spautin 1 - MBCQ derivative C43
產(chǎn)品貨號 Axon 2512 CAS [1262888-28-7] MF C15H11F2N3MW 271.26 Purity: 99% Soluble in DMSO Description Inhibitor of USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes, thereby promoting the degradation of Vps34 PI3 kinase complexes. Beclin1 is a tumor suppressor and regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Moreover, Spautin 1 inhibits autophagy which enhances imatinib-induced apoptosis in chronic myeloid leukemia. The pro-apoptotic activity of Spautin-1 was also associated with activation of GSK-3β, an important downstream effector of PI3K/AKT. KEYWORDS: Spautin 1 | supplier | USP10-USP13 inhibitor | MBCQ derivative C43 | Spautin1 | CAS [1262888-28-7] | Ubiquitin | Deubiquitinase | Beclin 1 | Vps34 | PI3K | Akt | p53 | apoptosis | autophagy | GSK-3β
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Spautin 1 - MBCQ derivative C43

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2512

CAS [1262888-28-7]

MF C15H11F2N3
MW 271.26

  • Purity: 99%
  • Soluble in DMSO

Spautin 1

Description

Inhibitor of USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes, thereby promoting the degradation of Vps34 PI3 kinase complexes. Beclin1 is a tumor suppressor and regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Moreover, Spautin 1 inhibits autophagy which enhances imatinib-induced apoptosis in chronic myeloid leukemia. The pro-apoptotic activity of Spautin-1 was also associated with activation of GSK-3β, an important downstream effector of PI3K/AKT.

KEYWORDS: Spautin 1 | supplier | USP10-USP13 inhibitor | MBCQ derivative C43 | Spautin1 | CAS [1262888-28-7] | Ubiquitin | Deubiquitinase | Beclin 1 | Vps34 | PI3K | Akt | p53 | apoptosis | autophagy | GSK-3β
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