產(chǎn)品名稱 CM1
產(chǎn)品貨號(hào) Axon 2479 CAS [1643659-63-5] MF C14H22N2O3MW 266.34 Purity: 100% Soluble in water and DMSO Description Orally active iron chelator with high af?nity and selectivity for iron(III) (relative metal complex stability constants of pFe(III)= 20.3; pCu(II)= 9.8; pZn(II)= 6.2) and a suit-able partition coef?cient to permeate membranes. CM1 is able to penetrate hepatocytes and relatively non toxic. Potential therapeutic for patients suffering from thalassaemia related iron overload Moreover, CM1 shows an inhibitory effect on the growth of Plasmodium falciparum (malaria parrasite; IC50 value 35 μM). KEYWORDS: CM1 | supplier | Iron chelator | CAS [1643659-63-5] | Iron (III) | FE(III) | Chelator | thalassaemia | hepatocytes | malaria | parasite | Plasmodium
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CM1

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2479

CAS [1643659-63-5]

MF C14H22N2O3
MW 266.34

  • Purity: 100%
  • Soluble in water and DMSO

CM1

Description

Orally active iron chelator with high af?nity and selectivity for iron(III) (relative metal complex stability constants of pFe(III)= 20.3; pCu(II)= 9.8; pZn(II)= 6.2) and a suit-able partition coef?cient to permeate membranes. CM1 is able to penetrate hepatocytes and relatively non toxic. Potential therapeutic for patients suffering from thalassaemia related iron overload Moreover, CM1 shows an inhibitory effect on the growth of Plasmodium falciparum (malaria parrasite; IC50 value 35 μM).

KEYWORDS: CM1 | supplier | Iron chelator | CAS [1643659-63-5] | Iron (III) | FE(III) | Chelator | thalassaemia | hepatocytes | malaria | parasite | Plasmodium
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