產(chǎn)品名稱

SMER 28

產(chǎn)品貨號(hào)

Axon 2627 CAS [307538-42-7] MF C11H10BrN3MW 264.12 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Small molecule enhancer of rapamycin that enhances the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington’s and Parkinson’s disease, independent of mTOR and Atg5 pathways. SMER28 also promotes reprogramming of fibroblasts (the conversion efficiency for adult tail-tip fibroblasts in particular) into neural stem cells, if combined with RG108 (Axon 1691) and Parnate. KEYWORDS:?SMER 28 | supplier | Autophagy inducer; SMER | SMER28 | SMER-28 | CAS [307538-42-7] | Small molecule enhancer of rapamycin | SMER | clearance | Huntington’s | Parkinson’s | reprogramming | fibroblasts | neural stem cells

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現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SMER 28

Based on 7 publications in PubMed 9 10 7

Axon 2627

CAS [307538-42-7]

MF C11H10BrN3
MW 264.12

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

SMER 28

Description

Small molecule enhancer of rapamycin that enhances the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington’s and Parkinson’s disease, independent of mTOR and Atg5 pathways. SMER28 also promotes reprogramming of fibroblasts (the conversion efficiency for adult tail-tip fibroblasts in particular) into neural stem cells, if combined with RG108 (Axon 1691) and Parnate.

S Sarkar et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-8.

Y Tian et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.

S Nekova et al. Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/B preferentially within a protective bone marrow microenvironment. Br J Haematol. 2014 Oct;167(2):272-4.

M Zhang et al. harmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 May 5;18(5):653-67.

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Material Safety Data Sheet

Apoptosis CNS Immunology Stem Cell PI3K-Akt-mTOR Stem Cell Differentiator Unclassified Autophagy

Small molecule enhancer of rapamycin that enhances autophagy

Chemical name

N-allyl-6-bromoquinazolin-4-amine

Parent CAS No.

[307538-42-7]

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