產(chǎn)品名稱

KU 0060648 trihydrochloride

產(chǎn)品貨號(hào)

Axon 1584 CAS [881375-00-4] MF C33H34N4O4S.3HClMW 692.10 Purity: 99% Soluble in water and DMSO Description Potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. Product?is discontinued (Autumn 2016).? * The parent molecule of KU 0060648 (Axon 2604) is available online, and makes an excellent alternative for Axon 1584. KEYWORDS:?KU 0060648 trihydrochloride | supplier | DNA-PK inhibitor | KU0060648 HCl | CAS [881375-00-4] | DNA-RNA | DNA-PK | Inhibitor | PIKK | PI3K | cancer | DNA repair | DSB | double-strand breaks

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

KU 0060648 trihydrochloride

Based on 91 reference(s) in Google Scholar 9 10 91

Axon 1584

CAS [881375-00-4]

MF C33H34N4O4S.3HCl
MW 692.10

Purity: 99%
Soluble in water and DMSO

KU 0060648 trihydrochloride

Description

Potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases.
Product?is discontinued (Autumn 2016).?

* The parent molecule of KU 0060648 (Axon 2604) is available online, and makes an excellent alternative for Axon 1584.

C Cano et al. Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK). RSC 2009 meeting abstract O6.

C Cano et al. Development of potent water-soluble inhibitors of the DNA-dependent protein kinase (DNA-PK). NARI cancer conference 2010.

J Bardos et al. Radio- and chemosensitization through inhibition of DNA-PK by KU-0060648. Mol. Cancer Ther. 2009, 8(12 Suppl), A116.?

F Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin. Ther. Pat. 2009, 19(6), 775-799.

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology DNA-PK PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

DNA-PK inhibitor

Chemical name

2-(4-Ethyl-piperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxo-4H-chromen-8-yl)-dibenzothiophen-1-yl]-acetamide trihydrochloride

Parent CAS No.

[881375-00-4]

產(chǎn)品資料