產(chǎn)品名稱

CP 466722

產(chǎn)品貨號(hào)

Axon 1495 CAS [1080622-86-1] MF C17H15N7O2MW 349.35 Purity: 99% Soluble in DMSO Description Specific ATM inhibitor; no inhibition of PI3K or PI3K-like protein kinases (PIKK) or Abl kinase in cells; does inhibit cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects; highly recommended tool to rapidly and reversibly regulate ATM activity. KEYWORDS: CP 466722 | supplier | ATM inhibitor | CP466722 | CP-466722 | CAS [1080622-86-1] | DNA-RNA | DNA damage | cell cycle | checkpoint | ataxia-telangiectasia | radiosensitization

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CP 466722

Based on 82 reference(s) in Google Scholar 10 10 82

Axon 1495

CAS [1080622-86-1]

MF C17H15N7O2
MW 349.35

Purity: 99%
Soluble in DMSO

CP 466722

Description

Specific ATM inhibitor; no inhibition of PI3K or PI3K-like protein kinases (PIKK) or Abl kinase in cells; does inhibit cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects; highly recommended tool to rapidly and reversibly regulate ATM activity.

MD Rainey et al. Transient inhibition of ATM kinase is sufficient to inhance cellular sensitivity to ionizing radiation. Cancer Res. 2008, 68(18), 7466-7474.

F Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin. Ther. Pat. 2009, 19(6), 775-799.

List of publications using CP 466722 (Axon 1495) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology ATM p53-Tumor Suppression PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

ATM inhibitor

Chemical name

2-(6,7-Dimethoxy-quinazolin-4-yl)-5-pyridin-2-yl-2H-[1,2,4]triazol-3-ylamine

Parent CAS No.

[1080622-86-1]

產(chǎn)品資料