產(chǎn)品名稱

VU 6008667

產(chǎn)品貨號(hào)

Axon 2739 CAS [2092923-21-0] MF C24H17ClF2N2O2MW 438.85 Purity: 99% Optical purity: 98% e.e. Soluble in DMSO and Ethanol Description VU6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) with IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively. Moreover, VU6008667 has high CNS penetration and shows a desired short half-life in rat (t1/2 = 2.3 h) useful for addiction studies. KEYWORDS: VU 6008667 | supplier | M5 NAM | VU6008667 | VU-6008667 | CAS [2092923-21-0] | Acetylcholine | CHRM5 | NAM | Receptors | Addiction | Muscarinic

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現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

VU 6008667

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2739

CAS [2092923-21-0]

MF C24H17ClF2N2O2
MW 438.85

Purity: 99%
Optical purity: 98% e.e.
Soluble in DMSO and Ethanol

VU 6008667

Description

VU6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) with IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively. Moreover, VU6008667 has high CNS penetration and shows a desired short half-life in rat (t1/2 = 2.3 h) useful for addiction studies.

KM McGowan et al. Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

Certificate of Analysis
Material Safety Data Sheet

CNS CHRM5 A18

Selective NAM of M5 mAChR (CHRM5)

Chemical name

(S)-9b-(4-Chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one

Parent CAS No.

[2092923-21-0]

產(chǎn)品資料