產(chǎn)品名稱 SB 332235
產(chǎn)品貨號 Axon 2593 CAS [276702-15-9] MF C13H10Cl3N3O4SMW 410.66 Purity: 98% Soluble in 0.1N NaOH(aq) and DMSO Description Selective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 μM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria. KEYWORDS:?SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | ?TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis
產(chǎn)品價格 現(xiàn)貨詢價，電話：010-67529703
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產(chǎn)品品牌 axonmedchem
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SB 332235

Based on 62 reference(s) in Google Scholar 9 10 62

Axon 2593

CAS [276702-15-9]

MF C13H10Cl3N3O4S
MW 410.66

  • Purity: 98%
  • Soluble in 0.1N NaOH(aq) and DMSO

SB 332235

Description

Selective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 μM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria.

KEYWORDS:?SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | ?TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis
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