產(chǎn)品名稱

Poziotinib - HM781-36B

產(chǎn)品貨號(hào)

Axon 2920 CAS [1092364-38-9] MF C23H21Cl2FN4O3MW 491.34 Purity: 99% Soluble in DMSO Description Poziotinib is an irreversible pan-HER inhibitor with IC50 values of 0.0032 μM, 0.0053 μM and 0.0235 μM for HER1, HER2 and HER4, respectively. Poziotinib inhibited phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest. Moreover, poziotinib demonstrated potent antitumor activity in HER2 amplified gastric cancer cells, HER2-amplified breast cancer cells, and erlotinib-resistant NSCLC. KEYWORDS: Poziotinib | supplier | HER inhibitor | HM781-36B | CAS [1092364-38-9] | CAS[1429757-68-5] | Non Selective (Phosphorylation Substrates) | EGFR | ErbB2-HER2 | ErbB4-HER4 | Inhibitor | Receptors | Gastric cancer | NSCLC | Breast cancer

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現(xiàn)貨詢價(jià)，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Poziotinib - HM781-36B

Based on 17 reference(s) in Google Scholar 8 10 17

Axon 2920

CAS [1092364-38-9]

MF C23H21Cl2FN4O3
MW 491.34

Purity: 99%
Soluble in DMSO

Poziotinib

Description

Poziotinib is an irreversible pan-HER inhibitor with IC50 values of 0.0032 μM, 0.0053 μM and 0.0235 μM for HER1, HER2 and HER4, respectively. Poziotinib inhibited phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest. Moreover, poziotinib demonstrated potent antitumor activity in HER2 amplified gastric cancer cells, HER2-amplified breast cancer cells, and erlotinib-resistant NSCLC.

HJ Nam et al. Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer. Cancer Lett. 2011 Mar 28;302(2):155-65.

MY Cha et al. Antitumor activity of HM781-36B, a highly effective pan-HER inhibitor in erlotinib-resistant NSCLC and other EGFR-dependent cancer models. Int J Cancer. 2012 May 15;130(10):2445-54.

HJ Kim et al. Antitumor activity of HM781-36B, a pan-HER tyrosine kinase inhibitor, in HER2-amplified breast cancer cells. Anticancer Drugs. 2012 Mar;23(3):288-97.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology EGFR ErbB2-HER2 JAK-STAT RTK class I; EC 2.7.10.1

Irreversible pan-HER inhibitor

Chemical name

1-(4-(4-(3,4-Dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one

Parent CAS No.

[1092364-38-9]

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